Thesaurus - Pets

At some stage in your life as a horse owner, you may find it necessary to stable your horse. It may only be for a couple of nights, a week or a more permanent situation. No

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

matter your reason or the length of your horses stay, it is important that you clean the stable at least once a day.

So you arrive at your horse's stable with a che

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ery “Good Morning!”. You organize their breakfast, change there pajamas (rugs), maybe go for an early morning ride (nice and chilly on those crisp winter mornings). But no mat

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

er what else you do, there is one thing every owner of a stabled horse must do. And that is to clean up the mess, from the night before.

What a mess!! It really ama

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

zes me the mess one horse can make within 8-10 hours! I have been greeted with a wide variety of “Good Morning” situations from my horses over the years. From finding poo in t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e feed dish (which is still hanging on the door!), to finding poo right in front of the door in the walk way! No matter the mess, it still needs to be cleaned up. Not only c

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

an a dirty or poorly cleaned stable cause diseases to fester but it will smell bad too.

Here are some simply steps to help you in cleaning out your stable!

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

You will need a good stable fork/rake and a wheelbarrow or bucket.

It is always helpful if you can remove your horse from the stable. This way you

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

aren’t worried about him/her escaping. If you can't make sure they are tied up securely.

Remove any other objects which may get in your way, such as water buckets a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d horse toys.

Using your stable fork/rake remove all large visible piles of poo.

Remove any obvious wet patches.

Starting on either your left

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

or right in a circular pattern around the stable, toss a fork full of stable bedding towards the side of the stable, remove any poo or wet that this process uncovers.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

> Remember to dig down to the floor so that all the bedding gets exposed, and continue till you are back to where you started.

Your stable bedding should now be al

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

piled up around the sides of the stable and the floor exposed. If the floor seems wet (will be in most cases) it is great if you can leave it exposed for a few hours to dry o

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ut.

Starting at either the right or left, pull the bedding down from the edge with your stable rake, so that the bedding comes back to its original level and cover

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the previously exposed floor. Continue around till you are back at the start.

You may find that you need to smooth out the bedding so that it is level and covers

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the floor evenly.

I have always found it a good idea to leave an area in front of the door free from bedding, this will help reduce the bedding that gets ‘walked’ o

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

‘kicked’ out by your horse.

You may find that when cleaning, some bedding drifts into the water. It is always a good idea to clean out your horses’ water after fin

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ishing the stable.

It may be necessary to add some new bedding to you stable, this is usually done once a week, but depends on your horse.

It will also b

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

necessary to remove all bedding from your stable on a regular base. This will depend on numerous factors and is up to your discretion. If it is getting smelly - then its time

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

for a full clean out!

Now that you’re done, you can enjoy some quality time with your beloved horse!

Happy Horsing

Tina Williamso

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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