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Your male dog will appreciate the freedom you have given him in life through your decision to neuter. There are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

many behavioral and medical benefits to spaying and neutering your pet. You will also be doing your part in he

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ping reduce this countries pet overpopulation problem. Millions of dogs and cats are euthanized each year becau

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e there are too many animals to adopt and not enough homes for them.

Below are some facts and medical benefits

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

of neutering your male dog.

1. Your dog will have an 80% less chance of contracting Prostate Cancer.

2. Testi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ular Disease is practically eliminated.

3. Decrease in the desire to roam. Non-neutered male dogs can smell a

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

female in heat up to a five mile radius and they will do just about anything to get to that female.

4. The des

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

re to mark is eliminated. Non-neutered dogs feel the need to mark their territory to defend it from other dogs

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

hether it is inside on your furniture or outside in your yard.

5. Decreased aggression against other animals.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

t decreases fights, thus saving you aggravation and expensive veterinary bills.

6. You will have a much calmer

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

dog that is more motivated to please you rather than be preoccupied with undesirable sexual behavior.

7. The a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nnoying problem of mounting the legs of children and adults is eliminated.

8. Dogs enter puberty around 6 mont

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s of age. Neutering is beneficial at any age but especially before your dog enters puberty. At puberty your dog

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

will become more stubborn and protective so it is best to neuter before the negative behavioral problems start.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Below are some myths of neutering your male dog.

1. Neutering does not take away the male dogs ability to be

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

watch dog. He will be just as protective of his territory as he would be without the surgery.

2. Your dog wil

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

l not become fat or lazy from the surgery. This will happen from too much food or not enough exercise.

3. The

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

urgery will not hurt your dog. Neutering is a relatively painless procedure done by a licensed veterinarian.

Y

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ur dog will be free to love and please you and be a member of the family with improved health and behavior. Ple

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

se do your part to help the millions of unwanted animals that are euthanized each year and neuter your male dog

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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