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Antique clocks and watches were made using different materials, designs, styles, and sizes long, long ago. The ability to accurately iden

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tify and research on this antique clocks and watches are important then because of the diversity, as well as the number, of clock and wat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

chmakers and manufacturers around the world.

Back in Time

Time measurement has been one of the concerns of every developing civilizatio

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

in the world since time immemorial. No wonder that man devised ways to tell time. An example is the use of the world’s natural clock whi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ch is the sun and the mechanical ones such as clocks and watches.

If we are going to trace the history of clocks and watches, we would b

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

back to the late 14th century when the first clock was made. In the early years, as well as many centuries over, mechanical clocks and w

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

atches were so uncommon and made by few that only rulers and noblemen had such. The common people, especially those in Europe, have to re

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ly on the few public clocks that are existent.

The majority of clocks and watches made from the 15th to the middle of the 17th century a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e now mostly in museums and a small percentage in different individuals’ private collection. Most people will never set eyes on these tim

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ekeepers nor will be able to recognize them.

Those antique clocks and watches that were made during the 1800’s through the early 1900’s

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

re more in number since the periods mentioned were the time when clocks and watches were produced in mass quantities.

Things to Consider

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Many antique clock and watch collectors would agree that periods in history greatly influenced the materials and styles of clocks and w

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

atches, such that these timekeepers were not only used for time measurement, but as decoration as well. Also, they were made with such hi

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

h quality that with proper care and maintenance, they are apt to last several centuries.

They are the total opposite of most clocks and

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

watches that we have today, however. In a fast-paced world where everything is instant and disposable, clock and watch craftsmanship in t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e modern age can be considered of low quality compared to that of one or two centuries ago.

There are several things that you may take i

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nto consideration if you are a collector or just a one time buyer of an antique clock or watch - besides the fact that it should be inter

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

esting, beautiful, befitting your needs or you want it to be a part of your life and home for many years.

The General Condition - This

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s a very important factor in determining the value of the clock or watch. The timepiece should be competently restored and accurately re

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

gulated. If these aspects are not looked into, the clock or watch may just serve as decoration rather than both decorative and functional

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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