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1. Buying Timber

So you’re going to need timber but before you go out and buy any let me just say this. We must remember that one of the most important factors on building a case for a longcase clock is the timber, and we must re

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

member when these clocks were made in the late seventeenth early eighteenth century the timbers that were used would have been air dried, meaning the tree was cut down and left to rest for a period of time before being converted in

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to planks. This allowed for water to escape from the cells.

The planks were then put in stick and left to air dry until the moisture content came down to 16%, which took approximately one inch per year. The timber could then be use

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

without the fear of the timber cupping, twisting or moving.

Unfortunately today with our centrally heated houses and double-glazed windows, furniture made with 16 % moisture content would cup, split and bend. Therefore timber to

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

be used in furniture in todays world should be kiln dried to 10 or 11% moisture content.

To find kiln dried timbers at a reasonable price is becoming more difficult as most of our furniture industry has disappeared, and the furnitu

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e is of the mass produce pine type,or manufactured with man made boards and coming in flat pack. There are very few furniture makers making hard wood quality furniture in this country today, therefore the demand for kiln dried hard

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

woods is very low and is not financially viable to the big timber merchants whose main market is in the building industries and mainly concentrate on construction timber. (Softwoods).

2. So I always convert my timber as follows

1

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

uy the timber kiln dried at 12% moisture content, and 1-inch thick planks were possible.

2 Cut the planks to the required lengths allowing an inch or two at each end allowing for any dipping on the planer.

3 Put the timber through

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the planer, to clean and square.

(If you don’t have circular saw and planer / thicknesser your local joiner will be able to convert the timber for you).

4 Then stack in the house best place I’ve found is under the bed. (Prefera

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ly when the lady of the house is shopping)

This will allow the timber to move, and any twisting or cupping can be corrected later.

I know this may seem a lot of messing about and time wasting but believe me this will save you a lo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t of work and heart ache and embarrassment, especially if the clock is for somebody else, you don’t want a member of your family or God forbid a customer to ring you up to tell you the door on the hood or trunk of there beloved clo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ck won’t close because its bent. Trust me this can be a nightmare, I’ve had to bring clocks back and had to build new doors. It’s very hard on the pocket and pride, so do the job correctly from the start and as in all crafts, if t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e foundations are done correctly the top will shine.

3. Movement and Dial.

One of the biggest mistakes I have seen people make over the years when they have been building a case for a clock is to make the case before having the mo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

vement and dial. I think this is because the emphasis is on the case as a piece of furniture and not as a piece to tell the time. Cost is also a factor. There is a tendency to think I will make the case first and then buy the movem

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nt and dial. For example when a tutor at a local furniture college rang me to ask if I could come down and help as a number of students had chosen to make longcase clocks for there yearly project. They had spent many hours making so

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

me beautiful cases with intricate stringing and veneering, they were extremely good cases. But now found the movements and dials they had bought would not fit. Unfortunately this usually means major readjustment as it did in this pa

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ticular case.So always have your dial and movement before you start building your case. I know this should be common sense but you would be surprised how many people try it.

The process is always the same when we make a clock case,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

we draw the clock projecting out from the dial measurements, through the mask and through the hood door and to the hood, which gives us the correct width for the clock. Then the measurement is taken from the front of the dial to th

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

back-cock on the movement to give use the correct depth and proportions for the clock.

Making a longcase clock is probably one of the most gratifying project you can ever take on and once in place will be a source of satisfaction

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

and pride for you for many years to come as every one who see it will view it with grate admiration and the clock it’s self will become a much loved and cherished part of the family for generations to come as grandfather clocks do

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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