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Solid wood countertops are natural products made of wood from trees approximately 120 years old. Wood is a living material and the more moisture

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

receives, the more the wood countertop will expand. The wood we used in solid wood worktops has been previously kiln dried to a humidity level of

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

6%, and it is therefore important that the worktop is not exposed to a constantly high level of humidity. Normally the humidity level in kitchens

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

is approximately 50-70%.

The solid wood top must be attached to the cabinet box using only wood screws and washers. It is not recommended at al

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

to glue the top on the cabinet box; the top and the box expand and contract at different rates, therefore cracks might eventually appear, most p

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

robably on the cabinets' surface.

The proper way of installing a solid wood top is using metal fixings along the cabinet box.

The metal fixings

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

must be uniformly distributed throughout the length of the top, spaced at a 1' - 1.5' distance from each other. Across the width, the top is usua

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

lly fixed to each metal support with three screws, one in the middle, one toward the front edge and one toward the rear edge. The supports must b

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

perfectly leveled; otherwise tensions can develop in the wood, leading to warping, cupping, or cracks.

We recommend pre-drilling the screw hole

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s into the wood countertop, in order to avoid cracks and splits. For the same reason, it is a good idea not to over tighten the screws. The fini

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hing will considerably diminish the extent of such movements, but will not eliminate them altogether. Due to the panel's laminated structure, the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

lengthwise movements are insignificant, so the installer should pay attention to the movements occurring across the panel's width. In order to pr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

event the development of inner tensions, the holes in the metal fixings should be elongated in the direction of the movements.

When exposed to n

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rmal humidity levels - i.e. 50-60% - the worktop's width will expand by 1/12”-1/24”, but when exposed to a level of 80-90%, this measurement may

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

expand by up to 1/2" or even more for some species. Therefore, when the rear edge of the counter top is installed against a wall, the wall might

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

estrict the top's natural movements, leading to undesired tensions in the wood. To avoid this, you can allow a 1/4”-1/2” joint between the wall a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nd the countertop edge and caulk it with a thin bid of acid-free silicone.

Additionally, you can firmly fix the rear edge to the metal supports

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nderneath and thus, allow the natural movements to occur at the expense of the opposite edge.

In this case, the holes in the metal fixings corre

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

sponding to the rear edge will be no larger than the screws diameter, while the holes corresponding to the middle section and the front edge will

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

be elongated.

For additional information regarding the installation of wood countertops, bar tops and kitchen islands, please visit our web page

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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