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Some signs of a leaky basement are very obvious and others are not so obvious. Of course the most obvious sign of water leaking is water everywhere or pools of water on

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the floor! You might also actually hear the water dripping or staring at big ugly brown stains spreading across your walls. Sometimes you can even smell the water part

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

icularly if it is tainted by sewage or tainted by pesticides. Sometimes leaky water also has the heavy musky smell of fresh soil as often water leaking through a bad b

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

asement foundation will also be carrying a lot of silt with it.

There are also lots of other clues that you have a leaky basement. One sign of a leaky basement that is

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

often just interpreted as aging or fading is the presence of efflorescence. Efflorescence is a deposit of a thin white film on your wall. It is the residue left by wat

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

er that contains minerals and other effluvia from the soil.

Dampness is of course a big sign that you have a leaky basement but you should also look for other signs su

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ch as rusting nails or metal fixtures, rotting wood near the floor level, rusted metal feet on appliances, lifted floor tiles and peeling paint. All of these signs are

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

not necessarily indicative of big disaster however it is possibly an indication that your home is suffering some kind of leakage during a rainy or wet season.

Sometime

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s the leaky basement is not due to some sort of vulnerability in your basement foundation. Sometimes it is caused by breaks in your water supply lines or pipes. Even a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

small seam or crack in a pipe can cause a big pool of water to form on your basement floor. Yet another big culprit is sinks and toilets that constantly drip as the res

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ult of a loose joint or loose pipe. Often this type of water collects beneath a cupboard in which the actual plumbing works are concealed.

There is almost always a lit

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tle bit of leakage around the places where pipes enter the home. This is because of condensation on the pipes forming dew. To prevent this type of water leaking into yo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ur house (and first make sure that it is not the pipe itself that is leaking or your efforts will be futile) you can patch it with a waterproof concrete patch. Keep in

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

mind that this will not prevent the water from forming from behind the walls. The only thing that might prevent that is the installation of a dehumidifier. Dehumidifie

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rs can be an important tool in your battle against basement moisture and molds but not if the moisture is actually due to water seepage as opposed to water condensation

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

.

There is a very easy way to determine if water on your basement walls is due to condensation or seepage. Simply tape a piece of aluminum foil to your basement wall.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

After a few days inspect its surfaces. If there is moisture on the inside surface that was touching the wall then you are dealing with a leak. If moisture forms on the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

aluminum foil side that is facing out from the wall then the problem is condensation and can easily be dealt with by a dehumidifier.

The good news is that condensation

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is a lot easier to manage than leaking water. Although it is persistent the excess humidity is manageable. Exposure to sunlight and wind can help dry out a basement th

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

at is dripping with condensation. It is also a good idea to keep basement windows closed if you live in a climate that is overly humid or that has a heavy rainy season.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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