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The universal appeal of Italy cannot be denied. It's a stunningly beautiful nation blessed with mountains, lakes, chic cities and ancient villages; it is set apart by its perfect climate and its dramati

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

c coastline which is caressed by the warm waters of the Mediterranean Sea.

Therefore is it any wonder that so many of us dream of buying property in Italy so that we can own our very own romantic Italia

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n retreat?

Whether you have ambitions of owning a stylish apartment in one of Italy's vibrant cities or a run down rustic farmhouse overlooking the rolling Italian countryside or even a villa by the sea

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

this is your essential cut out and keep guide to buying property in Italy!

There are no restrictions on the foreign ownership of real estate in Italy which means that the buying process is relatively st

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

raightforward and transparent. The first most important piece of advice to impart to would-be buyers though is to secure the services of an independent lawyer who can work on your behalf and translate k

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

y documents into English for example and basically just act on your behalf to ensure that you get the best deal possible.

A second important piece of advice is that those planning on buying a property i

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n Italy to live in permanently should sort out their residency status first as this will ultimately save them up to seven percent purchase tax – which equates to quite a hefty saving! In terms of fees,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

axes and additional expenses a buyer incurs in Italy, if you allow for an additional 10 or 12% on top of the purchase price this should cover everything.

There are many estate agents in Italy and it's w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ise to contact a few with your requirements to ensure that you get a broad perspective of the market and what you can get for your money. When you travel to Italy to view properties allow yourself plent

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

of time to acclimatise, get used to the areas you're looking for property in and to familiarise yourself with the delights of Italy – BUT, don't allow yourself to be seduced by the dream of living in It

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

aly, keep your feet firmly on the ground and view properties with a critical eye bearing in mind that an estate agent will be loath to tell you about any issues with the property.

If you're buying a rur

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

al property or one in need of renovation consider asking questions about the title deeds of the property, access, boundaries, your rights to water and electricity and then have the property independently

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

surveyed and valued before making any offer to purchase. If renovation work will need to be undertaken have a builder quote you for the work because getting building work done in Italy is one area where

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

expenses can spiral. Get a handle on what you'll really be buying into before you make a commitment!

Once you find a property you like the look of you can make an offer to purchase which if accepted w

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ll be valid for up to two weeks while preliminary contracts are drawn up. Your lawyer should check the contracts which will be prepared by a public notary. When you sign you will pay a deposit of betwe

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

en 10 and 30% and if you subsequently withdraw from the sale after signing this contract you will lose your deposit – on the other hand if the seller withdraws from the sale they have to pay you back dou

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

le your deposit. This is standard practice but make sure it is written into the contract anyway…and get anything promised or assumed written in as well.

As stated the public notary will handle the term

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s of the sale and draw up all contracts but your lawyer should be sure to check all details, title deeds, building permissions etc., to make sure that your best interests are looked after. The final sta

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e of the buying property in Italy transaction is signing the final contract if all is found to be in order when sea

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

rches are carried out by your lawyer. You will then transfer the balance of payment to the vendor and title deeds can be transferred into your name and you will become the proud owner of a home in Italy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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As a property owner, you are responsible for 100 percent of the clean up! Cleanups of labs are extremely resource-intensive and costly. The average cost of a cleanup is about $5,000. This is if you are lucky!

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